Parameter

Healthy S              BS

Infected S              BS

LSD (Pr > F)

t_1/2(ab) (h)

7.72 (1.07)^a

7.37 (0.19)^ab

6.87 (0.38)^b

8.11 (0.27)^a

0.791 (0.0256)

C_max (μg∙ml⁻¹)

1.33 (0.25)^b

1.40 (0.04)^b

1.36 (0.05)^b

1.70 (0.08)^a

0.180 (0.0016)

t_max (h)

7.21 (0.11)^a

7.11 (0.21)^a

7.15 (0.16)^a

7.10 (0.08)^a

0.198 (0.6369)

t_1/2(b) (h)

24.60 (0.43)^b

33.74 (1.86)^a

25.85 (1.39)^b

31.78 (2.05)^a

2.096 (0.0001)

AUC (μg∙h⁻¹∙l⁻¹)

67.58 (4.16)^c

83.7317.53)^ab

70.24 (8.24)^bc

84.91 (8.14)^a

14.36 (0.0397)

AUC_BS/AUC_S

1.24 (0.26)^a

1.22 (0.20)^a

0.338 (0.9196)

F (AUC_SC/AUC_IV)

0.916 (0.02)^a

0.875 (0.16)^a

0.839 (0.07)^a

0.813 (0.06)^a

0.122 (0.3401)